Kidney transplantation can be a life-changing treatment for patients with end-stage renal disease. However, the days and weeks following the surgery are critical. Early identification of abnormal symptoms can prevent serious complications such as graft rejection, infections, or kidney failure.

✅ Normal Symptoms in the First Few Days

  • Increased urination – a sign that the new kidney is working
  • Mild fatigue or weakness after surgery
  • Moderate incision pain or bruising
  • Improved appetite due to steroid medication

Note: These symptoms are expected and usually resolve on their own. Monitor them, but don’t panic unless they worsen.

⚠️ Critical Warning Signs After Kidney Transplant

  • Decreased or no urine output – possible sign of kidney failure or acute rejection
  • Body swelling – particularly in the legs, scrotum, abdomen, or face
  • Sudden weight gain (over 2–3 kg in a few days) – may indicate fluid retention
  • Fever or chills – potential infection or early rejection
  • High or low blood pressure – may reflect graft dysfunction or infection
  • Shortness of breath – could be due to fluid in lungs or heart complications
  • Extreme fatigue, confusion, or drowsiness – may signal electrolyte imbalance or toxin buildup
  • Sudden pain in the graft area – may suggest infection or acute rejection

💊 Drug-Related Side Effects to Monitor

Common immunosuppressive medications (like tacrolimus, cyclosporine, mycophenolate, prednisone) can cause:

  • Dry mouth or metallic taste
  • Shaking hands (tremors)
  • Increased blood sugar and cholesterol
  • Anxiety, insomnia, or mood swings
  • Greater risk of infections

Regular blood level checks for these drugs are essential to avoid toxicity or underdosage.

🔬 Recommended Post-Transplant Tests

Test Why It Matters
Creatinine, BUN Check kidney function
Electrolytes (Na, K, Mg) Prevent dangerous imbalances
Albumin Evaluate fluid retention risk
Complete Blood Count (CBC), CRP Detect infections or inflammation
Immunosuppressant drug levels Ensure safe and effective dosing
Urinalysis (U/A) Monitor for protein or blood in urine

🟢 Final Tips

Always track your daily weight, urine output, and any swelling. Early changes may be the only sign something is wrong. Never hesitate to contact your transplant team if anything feels unusual – even mild changes can be serious.

📌 Pro Tip

If you’re in another country or far from your transplant center, keep a daily log of symptoms and communicate regularly with your doctor via email, phone, or telemedicine. Send photos if swelling occurs.

Stay alert. Early action saves transplants – and lives.